GOLD NANOPARTICLES EFFECTS ON THE MORPHOFUNCTIONAL STATE OF THE HYPOTHALAMUS AND ADRENAL CORTEX OF RATS WITH OBESITY

The aim of our study was to compare the effects a gold salt (sodium tetrachloroaurate) and nanoparticles colloidal solution on morphofunctional state hypothalamus adrenal glands 6-month-old male rats with obesity, which induced using diet-induced model metabolic disorders. rats, modeled for were divided into three groups that received NaCl solution, 10 days. Rats control group standard diet. After end experiment, hypothalamic nuclei glands, prepared according appropriate histological methods, collected from animals. In paraventricular nucleus hypothalamus, small-cell area neurons examined. cells zones cortex examined: glomerular, fascicular, reticular. results showed obesity led increase functional activity in region rat hypothalamus. Functional increased maximally glomerular zone cortex, moderately fascicular zone, no significant changes recorded reticular zone. It shown caused decrease obese rats. significantly decreased; parameters cell decreased greater extent; there almost changes. introduction intensification cytoplasmic decreased, but nuclear did not change; measured values remained unchanged. general, administration produced more pronounced than